Journal
JOURNAL OF NATURAL PRODUCTS
Volume 82, Issue 8, Pages 2299-2306Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b00603
Keywords
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Funding
- (Japan Society for the Promotion of Science OSPS) [15H04491, 16K14910]
- [16K07474]
- Grants-in-Aid for Scientific Research [16K14910] Funding Source: KAKEN
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An efficient protocol for calculating C-13 NMR chemical shifts for natural products with multiple degrees of conformational freedom is described. This involves a multistep procedure starting from molecular mechanics and ending with a large basis set density functional model to obtain accurate Boltzmann conformer weights, followed by empirically corrected density functional NMR calculations for the individual conformers. The accuracy of the protocol (average rms <4 ppm) was determined by application to similar to 925 diverse natural products, the structures of which have been confirmed either by X-ray crystallography or independent synthesis. The protocol was then applied to similar to 2275 natural products, the structures of which were elucidated mainly by NMR and MS data. Five to ten percent of the latter compounds exhibited rms errors significantly in excess of 4 ppm, suggesting possible structural or signal assignment errors. Both data sets are available from an online browser (NMR.wavefun.com). The procedure can be and has been fully automated and is practical using present-generation personal computers, requiring a few hours or days depending on the size of the molecule and number of accessible conformers.
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