Journal
JOURNAL OF NATURAL PRODUCTS
Volume 82, Issue 8, Pages 2174-2180Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b00182
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Funding
- Thailand Research Fund (TRF)
- University of Phayao [RSA5980010]
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The chromatographic separation of the components of the acetone extract of Mallotus philippensis fruits yielded five new phenolic compounds including two chalcones, 1 and 3, a functionalized phloroglucinol, 2, two flavanones, 4 and 5, and six known compounds. The structures of 1-5 were confirmed by NMR and mass analyses. Racemic compounds 1 and 2 were separated by chiral-phase HPLC, and the absolute configuration of (+)-1 was confirmed by X-ray diffraction studies and ECD spectroscopic data. The configurations of the enantiomers of 2 were defined by comparison of its ECD data with those of (+)-1. Compounds 6 and 7 exhibited significant antibacterial activities, with MIC values ranging from 3.8 to 15.5 mu M.
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