Related references
Note: Only part of the references are listed.A new twist on tropomyosin binding to actin filaments: perspectives on thin filament function, assembly and biomechanics
William Lehman et al.
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY (2020)
Congenital myopathy-related mutations in tropomyosin disrupt regulatory function through altered actin affinity and tropomodulin binding
Joanna Moraczewska et al.
FEBS JOURNAL (2019)
Spontaneous transitions of actin-bound tropomyosin toward blocked and closed states
Farooq A. Kiani et al.
JOURNAL OF GENERAL PHYSIOLOGY (2019)
Effects of cardiomyopathy-linked mutations K15N and R21H in tropomyosin on thin-filament regulation and pointed-end dynamics
Thu Ly et al.
MOLECULAR BIOLOGY OF THE CELL (2019)
Tropomyosin isoforms differentially tune actin filament length and disassembly
Silvia Jansen et al.
MOLECULAR BIOLOGY OF THE CELL (2019)
Structural destabilization of tropomyosin induced by the cardiomyopathy-linked mutation R21H
Thu Ly et al.
PROTEIN SCIENCE (2018)
HCM and DCM cardiomyopathy-linked α-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments
Gerrie P. Farman et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2018)
Functional effects of substitutions I92T and V95A in actin-binding period 3 of tropomyosin
Malgorzata Sliwinska et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2018)
Skeletal myosin binding protein-C isoforms regulate thin filament activity in a Ca2+-dependent manner
Brian Leei Lin et al.
SCIENTIFIC REPORTS (2018)
N-Terminal Domains of Cardiac Myosin Binding Protein C Cooperatively Activate the Thin Filament
Cristina Risi et al.
STRUCTURE (2018)
Ca2+-induced movement of tropomyosin on native cardiac thin filaments revealed by cryoelectron microscopy
Cristina Risi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
The cardiomyopathy-associated K15N mutation in tropomyosin alters actin filament pointed end dynamics
Mert Colpan et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2017)
Clinically Divergent Mutation Effects on the Structure and Function of the Human Cardiac Tropomyosin Overlap
Mark McConnell et al.
BIOCHEMISTRY (2017)
Tropomodulins and Leiomodins: Actin Pointed End Caps and Nucleators in Muscles
Velia M. Fowler et al.
BIOPHYSICAL JOURNAL (2017)
Tropomyosin-binding properties modulate competition between tropomodulin isoforms
Mert Colpan et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2016)
Localization of the binding interface between leiomodin-2 and α-tropomyosin
Mert Colpan et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2016)
Tropomyosins in the healthy and diseased nervous system
Merryn Brettle et al.
BRAIN RESEARCH BULLETIN (2016)
TNNI1, TNNI2 and TNNI3: Evolution, regulation, and protein structure-function relationships
Juan-Juan Sheng et al.
GENE (2016)
TNNTI, TNNT2, and TNNT3: Isoform genes, regulation, and structure-function relationships
Bin Wei et al.
GENE (2016)
Investigating the effects of tropomyosin mutations on its flexibility and interactions with filamentous actin using molecular dynamics simulation
Wenjun Zheng et al.
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY (2016)
Comprehensive analysis of tropomyosin isoforms in skeletal muscles by top-down proteomics
Yutong Jin et al.
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY (2016)
Distribution of tropomyosin isoforms in different types of single fibers isolated from bovine skeletal muscles
M. Oe et al.
MEAT SCIENCE (2016)
The N-terminal tropomyosin- and actin-binding sites are important for leiomodin 2's function
Thu Ly et al.
MOLECULAR BIOLOGY OF THE CELL (2016)
Tropomyosin-Mediated Regulation of Cytoplasmic Myosins
Dietmar J. Manstein et al.
TRAFFIC (2016)
Tropomyosin diffusion over actin subunits facilitates thin filament assembly
Stefan Fischer et al.
STRUCTURAL DYNAMICS-US (2016)
Thin Filament Structure and the Steric Blocking Model
William Lehman
COMPREHENSIVE PHYSIOLOGY (2016)
Impaired tropomyosin-troponin interactions reduce activation of the actin thin filament
Katarzyna Robaszkiewicz et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2015)
Muscle weakness in TPM3-myopathy is due to reduced Ca2+-sensitivity and impaired acto-myosin cross-bridge cycling in slow fibres
Michaela Yuen et al.
HUMAN MOLECULAR GENETICS (2015)
Tropomyosin - master regulator of actin filament function in the cytoskeleton
Peter W. Gunning et al.
JOURNAL OF CELL SCIENCE (2015)
Mechanisms of leiomodin 2-mediated regulation of actin filament in muscle cells
Xiaorui Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
How Leiomodin and Tropomodulin use a common fold for different actin assembly functions
Malgorzata Boczkowska et al.
NATURE COMMUNICATIONS (2015)
Mechanistic Heterogeneity in Contractile Properties of alpha-Tropomyosin (TPM1) Mutants Associated with Inherited Cardiomyopathies
Tejas M. Gupte et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
A systematic nomenclature for mammalian tropomyosin isoforms
Michael A. Geeves et al.
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY (2015)
Structure of the F-actin-tropomyosin complex
Julian von der Ecken et al.
NATURE (2015)
Energy landscapes reveal the myopathic effects of tropomyosin mutations
Marek Orzechowski et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2014)
Cofilin-2 Controls Actin Filament Length in Muscle Sarcomeres
Elena Kremneva et al.
DEVELOPMENTAL CELL (2014)
Mutation Update and Genotype-Phenotype Correlations of Novel and Previously Described Mutations in TPM2 and TPM3 Causing Congenital Myopathies
Minttu Marttila et al.
HUMAN MUTATION (2014)
Differential Actin-regulatory Activities of Tropomodulin1 and Tropomodulin3 with Diverse Tropomyosin and Actin Isoforms*
Sawako Yamashiro et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
The myosin-activated thin filament regulatory state, M - -open: a link to hypertrophic cardiomyopathy (HCM)
Sherwin S. Lehrer et al.
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY (2014)
Mechanism of actin filament pointed-end capping by tropomodulin
Jampani Nageswara Rao et al.
SCIENCE (2014)
Gene regulation, alternative splicing, and posttranslational modification of troponin subunits in cardiac development and adaptation: a focused review
Juan-Juan Sheng et al.
FRONTIERS IN PHYSIOLOGY (2014)
Nebulin interactions with actin and tropomyosin are altered by disease-causing mutations
Minttu Marttila et al.
SKELETAL MUSCLE (2014)
Mutations in repeating structural motifs of tropomyosin cause gain of function in skeletal muscle myopathy patients
Steven Marston et al.
HUMAN MOLECULAR GENETICS (2013)
Cryo-EM Structures of the Actin:Tropomyosin Filament Reveal the Mechanism for the Transition from C- to M-State
Duncan R. Sousa et al.
JOURNAL OF MOLECULAR BIOLOGY (2013)
In-depth proteomic analysis of human tropomyosin by top-down mass spectrometry
Ying Peng et al.
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY (2013)
Tropomodulins and tropomyosins: working as a team
Mert Colpan et al.
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY (2013)
Alpha-tropomyosin mutations in inherited cardiomyopathies
Charles Redwood et al.
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY (2013)
Polymorphism in tropomyosin structure and function
Miro Janco et al.
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY (2013)
Thin-filament length correlates with fiber type in human skeletal muscle
David S. Gokhin et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2012)
The flexibility of two tropomyosin mutants, D175N and E180G, that cause hypertrophic cardiomyopathy
Xiaochuan (Edward) Li et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)
Long-Range Effects of Familial Hypertrophic Cardiomyopathy Mutations E180G and D175N on the Properties of Tropomyosin
Socheata Ly et al.
BIOCHEMISTRY (2012)
Functional effects of congenital myopathy-related mutations in gamma-tropomyosin gene
Katarzyna Robaszkiewicz et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2012)
Structure of the Rigor Actin-Tropomyosin-Myosin Complex
Elmar Behrmann et al.
CELL (2012)
Normal myofibrillar development followed by progressive sarcomeric disruption with actin accumulations in a mouse Cfl2 knockout demonstrates requirement of cofilin-2 for muscle maintenance
Pankaj B. Agrawal et al.
HUMAN MOLECULAR GENETICS (2012)
Congenital myopathy-causing tropomyosin mutations induce thin filament dysfunction via distinct physiological mechanisms
Julien Ochala et al.
HUMAN MOLECULAR GENETICS (2012)
Genetic Testing for Dilated Cardiomyopathy in Clinical Practice
Neal K. Lakdawala et al.
JOURNAL OF CARDIAC FAILURE (2012)
DCM-Related Tropomyosin Mutants E40K/E54K Over-Inhibit the Actomyosin Interaction and Lead to a Decrease in the Number of Cycling Cross-Bridges
Fan Bai et al.
PLOS ONE (2012)
Several cardiomyopathy causing mutations on tropomyosin either destabilize the active state of actomyosin or alter the binding properties of tropomyosin
Mohit C. Mathur et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)
Tropomyosin: Double helix from the protein world
I. A. Nevzorov et al.
BIOCHEMISTRY-MOSCOW (2011)
Tropomyosin Position on F-Actin Revealed by EM Reconstruction and Computational Chemistry
Xiaochuan (Edward) Li et al.
BIOPHYSICAL JOURNAL (2011)
Identification of Residues within Tropomodulin-1 Responsible for Its Localization at the Pointed Ends of the Actin Filaments in Cardiac Myocytes
Takehiro Tsukada et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Facilitated Cross-Bridge Interactions with Thin Filaments by Familial Hypertrophic Cardiomyopathy Mutations in alpha-Tropomyosin
Fang Wang et al.
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2011)
The 3-state model of muscle regulation revisited: is a fourth state involved?
Sherwin S. Lehrer
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY (2011)
Evolutionarily conserved surface residues constitute actin binding sites of tropomyosin
Bipasha Barua et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Localization of the two tropomyosin-binding sites of troponin T
J. -P. Jin et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2010)
Leiomodin-2 is an antagonist of tropomodulin-1 at the pointed end of the thin filaments in cardiac muscle
Takehiro Tsukada et al.
JOURNAL OF CELL SCIENCE (2010)
What makes tropomyosin an actin binding protein? A perspective
Sarah E. Hitchcock-DeGregori et al.
JOURNAL OF STRUCTURAL BIOLOGY (2010)
Different Localizations and Cellular Behaviors of Leiomodin and Tropomodulin in Mature Cardiomyocyte Sarcomeres
Aneta Skwarek-Maruszewska et al.
MOLECULAR BIOLOGY OF THE CELL (2010)
Forster Resonance Energy Transfer Structural Kinetic Studies of Cardiac Thin Filament Deactivation
Jun Xing et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Two-crystal structures of tropomyosin C-terminal fragment 176-273:: Exposure of the hydrophobic core to the solvent destabilizes the tropomyosin molecule
Shiho Minakata et al.
BIOPHYSICAL JOURNAL (2008)
Gestalt-binding of tropomyosin to actin filaments
Kenneth C. Holmes et al.
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY (2008)
Leiomodin is an actin filament nucleator in muscle cells
David Chereau et al.
SCIENCE (2008)
Molecular basis of tropomyosin binding to tropomodulin, an actin-capping protein
Alla S. Kostyukova et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
Leiomodin/tropomyosin interactions are isoform specific
Alla S. Kostyukova
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2007)
Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity
Sudarsan Rajan et al.
CIRCULATION RESEARCH (2007)
The effect of mutations in α-tropomyosin (E40K and E54K) that cause familial dilated cardiomyopathy on the regulatory mechanism of cardiac muscle thin filaments
Mahmooda Mirza et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Solution NMR structure of the junction between tropomyosin molecules: Implications for actin binding and regulation
Norma J. Greenfield et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
A comparison of muscle thin filament models obtained from electron microscopy reconstructions and low-angle X-ray fibre diagrams from non-overlap muscle
Katrina J. V. Poole et al.
JOURNAL OF STRUCTURAL BIOLOGY (2006)
Structure of the mid-region of tropomyosin: Bending and binding sites for actin
JH Brown et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Functional consequences of hypertrophic and dilated cardiomyopathy-causing mutations in α-tropomyosin
AN Chang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Dilated cardiomyopathy mutations in three thin filament regulatory proteins result in a common functional phenotype
M Mirza et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
An alpha-Tropomyosin mutation alters dimer preference in nemaline myopathy
MA Corbett et al.
ANNALS OF NEUROLOGY (2005)
Ca2+-induced rolling of tropomyosin in muscle thin filaments -: The α- and β-band hypothesis revisited
LMF Holthauzen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Effects of two familial hypertrophic cardiomyopathy mutations in α-tropomyosin, Asp175Asn and Glu180Gly, on the thermal unfolding of actin-bound tropomyosin
E Kremneva et al.
BIOPHYSICAL JOURNAL (2004)
Functions of tropomyosin's periodic repeats
SE Hitchcock-DeGregori et al.
BIOCHEMISTRY (2002)
Tropomyosin 3 expression leads to hypercontractility and attenuates myofilament length-dependent Ca2+ activation
K Pieples et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2002)
The troponin tail domain promotes a conformational state of the thin filament that suppresses myosin activity
LS Tobacman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Tropomyosin requires an intact N-terminal coiled coil to interact with tropomodulin
NJ Greenfield et al.
BIOPHYSICAL JOURNAL (2002)
A familial hypertrophic cardiomyopathy α-tropomyosin mutation causes severe cardiac hypertrophy and death in mice
R Prabhakar et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2001)
Mutations that alter the surface charge of alpha-tropomyosin are associated with dilated cardiomyopathy
TM Olson et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2001)
Alteration of tropomyosin function and folding by a nemaline myopathy-causing mutation
J Moraczewska et al.
BIOPHYSICAL JOURNAL (2000)
Tropomyosin 3 increases striated muscle isoform diversity
K Pieples et al.
BIOCHEMISTRY (2000)
Independent functions for the N- and C-termini in the overlap region of tropomyosin
J Moraczewska et al.
BIOCHEMISTRY (2000)
Regulation of contraction in striated muscle
AM Gordon et al.
PHYSIOLOGICAL REVIEWS (2000)