Journal
JOURNAL OF MOLECULAR STRUCTURE
Volume 1185, Issue -, Pages 450-460Publisher
ELSEVIER
DOI: 10.1016/j.molstruc.2019.02.098
Keywords
8-aminoquinoline; Acylthiourea; Chemosensor; Molecular docking; Antioxidant
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Funding
- University Grants Commission [F1-17.1/2012-13/RGNF-2012-13-ST-AND-18716]
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Acylthiourea derivatives, 1-benzoyl-3-(quinolin-8-yl) thiourea (1), 1-(furan-2-carbonyl)-3-(quinolin-8-yl) thiourea (2) and 1-(thiophene-2-carbonyl)-3-(quinolin-8-yl) thiourea (3) were synthesized and well characterized by using NMR (H-1 and C-13), FT-IR, UV-visible and mass spectroscopy tools. The molecular structures of compounds 1 and 3 were confirmed by single crystal X-ray crystallography. The fluorescence emission of the compounds (1-3) was studied using fluorescence spectrophotometer. The sensing ability of the acylthiourea derivatives was analyzed by colorimetric, UV-visible and fluorescence titrations. In silico anti-inflammatory, antimalarial and anti-tuberculosis activities were investigated using molecular docking studies. Acylthiourea derivatives also possessed good antioxidant activity. (C) 2019 Elsevier B.V. All rights reserved.
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