Journal
JOURNAL OF MEMBRANE BIOLOGY
Volume 252, Issue 4-5, Pages 413-423Publisher
SPRINGER
DOI: 10.1007/s00232-019-00078-1
Keywords
G protein-coupled receptor; Quaternary structure; Photoreceptor cell; Retina; Phototransduction; Retinal degeneration
Funding
- NEI NIH HHS [R01 EY021731] Funding Source: Medline
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Rhodopsin is the light receptor in photoreceptor cells of the retina and a prototypical G protein-coupled receptor. Two types of quaternary structures can be adopted by rhodopsin. If rhodopsin folds and attains a proper tertiary structure, it can then form oligomers and nanodomains within the photoreceptor cell membrane. In contrast, if rhodopsin misfolds, it cannot progress through the biosynthetic pathway and instead will form aggregates that can cause retinal degenerative disease. In this review, emerging views are highlighted on the supramolecular organization of rhodopsin within the membrane of photoreceptor cells and the aggregation of rhodopsin that can lead to retinal degeneration.
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