Journal
JOURNAL OF MAGNETIC RESONANCE IMAGING
Volume 51, Issue 4, Pages 1008-1029Publisher
WILEY
DOI: 10.1002/jmri.26846
Keywords
MRS; pulse sequences; J-editing; 2D spectroscopy; MQF
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This article reviews the most commonly used modern sequences designed to confront the two major challenges of in vivo magnetic resonance spectroscopy (MRS): spatial localization and metabolic specificity. The purpose of this review article is to provide a deeper and clearer understanding of the underlying mechanisms by which all modern MRS sequences operate. A descriptive explanation, consistent pulse sequence diagram, and theoretical concepts of the measured signal are given for five spatial localization sequences and three modules designed to increase metabolic specificity. Cross-sequence comparisons, including potential modifications for estimating quantitative measures like spin-lattice relaxation time T-1, spin-spin relaxation time T-2, and diffusion coefficients are briefly discussed. Technical Efficacy Stage: 1 J. Magn. Reson. Imaging 2020;51:1008-1029.
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