Journal
JOURNAL OF MAGNETIC RESONANCE
Volume 306, Issue -, Pages 102-108Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jmr.2019.07.038
Keywords
Pulse EPR; Distance measurements; PD-EPR; DEER; PELDOR
Funding
- Israel Science Foundation (ISF) National Natural Science Foundation of China (NSFC) [118768]
Ask authors/readers for more resources
Application of EPR to biological systems includes many techniques and applications. In this short perspective, which dares to look into the future, I focus on pulse EPR, which is my field of expertise. Generally, pulse EPR techniques can be divided into two main groups: (1) hyperfine spectroscopy, which explores electron-nuclear interactions, and (2) pulse-dipolar (PD) EPR spectroscopy, which is based on electron-electron spin interactions. Here I focus on PD-EPR because it has a better chance of becoming a widely applied, easy-to-use table-top method to study the structural and dynamic aspects of bio-molecules. I will briefly introduce this technique, its current state of the art, the challenges it is facing, and finally I will describe futuristic scenarios of low-cost PD-EPR approaches that can cross the diffusion barrier from the core of experts to the bulk of the scientific community. (C) 2019 Elsevier Inc. All rights reserved.
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