4.3 Article

Liposomal integration method for assessing antioxidative activity of water insoluble compounds towards biologically relevant free radicals: example of avarol

Journal

JOURNAL OF LIPOSOME RESEARCH
Volume 30, Issue 3, Pages 218-226

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1080/08982104.2019.1625378

Keywords

Liposomes; avarol; EPR; antioxidant; Dysidea avara

Funding

  1. Ministry of Education, Science and Technological Development of the Republic of Serbia [III 41005, OI 172053]

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The liposomal integration method, in conjunction with electron paramagnetic resonance (EPR) spectroscopy, has been presented for the investigation of antioxidant activity of selected water-insoluble compound towards biologically relevant free radicals. This method was applied to avarol, a sesquiterpenoid hydroquinone isolated from the marine sponge Dysidea avara. The antioxidant activity of water-insoluble avarol towards (OH)-O-center dot, O-2(center dot-) and NO center dot radicals was attained by its incorporation into the DPPC liposomes bilayer, and towards ascorbyl radicals in the organic solvent. Avarol's activity towards (OH)-O-center dot, O-2(center dot-), NO center dot and ascorbyl radicals was 86.2%, 50.9%, 23.6% and 61.8%, respectively, showing its significant radical scavenging potential.

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