Journal
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volume 140, Issue 2, Pages 284-290Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jid.2019.06.137
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Funding
- Helsinki Institute of Life Science (University of Helsinki)
- Wihuri Research Institute
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme [770877 - STEMpop]
- Academy of Finland
- Max Planck Society
- Erkko Foundation
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [73111208 - SFB 829]
- Human Frontier Science Program Long-Term Fellowship [LT000861/2018-L]
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Tissue shape emerges from the collective mechanical properties and behavior of individual cells and the ways by which they integrate into the surrounding tissue. Tissue architecture and its dynamic changes subsequently feed back to guide cell behavior. The skin is a dynamic, self-renewing barrier that is subjected to large-scale extrinsic mechanical forces throughout its lifetime. The ability to withstand this constant mechanical stress without compromising its integrity as a barrier requires compartment-specific structural specialization and the capability to sense and adapt to mechanical cues. This review discusses the unique mechanical properties of the skin and the importance of signals that arise from mechanical communication between cells and their environment.
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