Journal
JOURNAL OF INFECTION AND CHEMOTHERAPY
Volume 26, Issue 2, Pages 252-256Publisher
ELSEVIER
DOI: 10.1016/j.jiac.2019.07.002
Keywords
GATA binding protein 2; Monocytopenia; NK lymphocytopenia; B lymphocytopenia; Primary cytomegalovirus infection; Hemophagcytic lymphohistiocytosis
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We report a case of a 27-year old woman with persistent fever and pancytopenia who had multiple episodes of a hemophagocytic lymphohistiocytosis (HLH) like condition. The criterion for HLH was satisfied; primary cytomegalovirus (CMV) infection was identified as the cause. Further examination revealed a GATA binding protein 2 mutation. Reports of GATAs deficiency presenting with HLH after primary CMV infection is very limited. As early recognition and diagnosis will improve patients' outcomes, internists and infectious disease specialists should be aware of this disease. (c) 2019 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
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