Journal
APPLIED RADIATION AND ISOTOPES
Volume 115, Issue -, Pages 18-22Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2016.05.030
Keywords
Copper-64; Copper chloride; Biodistribution; Internal dosimetry; Pet; Theranostics
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Funding
- Consejo Nacional de Ciencia y Tecnologia Grant [179218]
- International Atomic Energy Agency Grant [RC20569]
- Universidad Nacional Autonoma de Mexico Grant DGAPA-PAPIIT [TT201115]
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The aim of this study was to obtain data on the biodistribution of (CuCl2)-Cu-64 in rats and to obtain estimates of the radiation doses to humans by extrapolating the animal data. MicroPET imaging and biodistribution studies were carried out with Wistar rats, and the doses were estimated with OLINDA/EXM. The lower large intestine wall was found to be the critical organ with an absorbed dose of 139 +/- 34 and 125 +/- 32 mu Gy/MBq for females and males, respectively. The corresponding effective doses were estimated as 47 +/- 4 and 39 +/- 4 mu Sv/MBq. (C) 2016 Elsevier Ltd. All rights reserved.
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