Journal
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
Volume 41, Issue 11, Pages 1208-1211Publisher
CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
DOI: 10.1139/apnm-2016-0326
Keywords
glucose transport; insulin signaling; dietary restriction; slow-twitch muscle; protein kinase B
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Funding
- NIA [AG-010026, AG-013283]
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Calorie restriction (CR; similar to 60%-65% of ad libitum consumption) can enhance insulin-stimulated glucose uptake (ISGU) in predominantly slow-twitch skeletal muscles (e.g., soleus) by an incompletely understood mechanism. We used an Akt inhibitor (MK-2206) to eliminate CR's effect on insulin-stimulated Akt2 phosphorylation in isolated rat soleus muscles. We found long-term CR-enhanced ISGU was abolished by eliminating the CR effect on Akt2 phosphorylation, suggesting the CR-induced benefit on ISGU in the predominantly slow-twitch soleus relies on enhanced Akt2 phosphorylation.
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