Journal
APPLIED PHYSICS LETTERS
Volume 108, Issue 24, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/1.4954015
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Funding
- MOST973 [2014CB339800]
- National Instrumentation Program [2012YQ14005]
- National Natural Science Foundation [61371035, 11173015, 11227904, 61521001, 61501219]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Jiangsu Provincial Key Laboratory of Advanced Manipulating Technique of Electromagnetic Wave
- Technological Development project of Shandong Province [2013GGA04021]
- Cooperative Innovation Centre of Terahertz Science, University of Electronic Science and Technology, Chengdu, China
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Label-free, real-time, and in-situ measurement on cell apoptosis is highly desirable in cell biology. We propose here a design of terahertz ( THz) metamaterial-based biosensor for meeting this requirement. This metamaterial consists of a planar array of five concentric subwavelength gold ring resonators on a 10 mu m-thick polyimide substrate, which can sense the change of dielectric environment above the metamaterial. We employ this sensor to an oral cancer cell ( SCC4) with and without cisplatin, a chemotherapy drug for cancer treatment, and find a linear relation between cell apoptosis measured by Flow Cytometry and the relative change of resonant frequencies of the metamaterial measured by THz time-domain spectroscopy. This implies that we can determine the cell apoptosis in a label-free manner. We believe that this metamaterial-based biosensor can be developed into a cheap, label-free, real-time, and in-situ detection tool, which is of significant impact on the study of cell biology. Published by AIP Publishing.
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