Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 294, Issue 30, Pages 11382-11390Publisher
ELSEVIER
DOI: 10.1074/jbc.AW119.008149
Keywords
cell cycle; cell division; cancer; chemical biology; computational biology; genomics; proteomics; protein structure; post-translational modification (PTM); classical genetics
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Funding
- National Institutes of Health NIGMS [R01GM117475]
- Ruth L. Kirschstein National Institutes of Health NRSA Award [GM007185]
- National Science Foundation [DGE-1650604]
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Cell division is a highly regulated and carefully orchestrated process. Understanding the mechanisms that promote proper cell division is an important step toward unraveling important questions in cell biology and human health. Early studies seeking to dissect the mechanisms of cell division used classical genetics approaches to identify genes involved in mitosis and deployed biochemical approaches to isolate and identify proteins critical for cell division. These studies underscored that post-translational modifications and cyclin-kinase complexes play roles at the heart of the cell division program. Modern approaches for examining the mechanisms of cell division, including the use of high-throughput methods to study the effects of RNAi, cDNA, and chemical libraries, have evolved to encompass a larger biological and chemical space. Here, we outline some of the classical studies that established a foundation for the field and provide an overview of recent approaches that have advanced the study of cell division.
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