Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 22, Issue 4, Pages 329-337Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2019.1576643
Keywords
Apostichopus japonicus; viscera; non-holostane; glycosides; structural identification; antitumor
Funding
- Public Science and Technology Research Funds Projects of Ocean [201505030]
- National Natural Science Foundation of China [81602982]
- Shandong Natural Science Foundation of China [ZR2016YL009]
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Two novel glycosides, apostichoposide A(1) (1) and B-1 (2), were isolated from the viscera of Chinese sea cucumbers (Apostichopus japonicus, Selenka) collected in the Bohai sea. Both the isolated glycosides were characterized by non-holostane type aglycones having 18(16)-lactone and 7(8)-double bond. Cytotoxic activities of the two compounds were evaluated against three human cancer cell lines. Compound 1 had adequate cytotoxic activity against MGC-803 and PC-3M cell lines. Our results indicated that glycosides present in A. japonicus viscera are an important high value resource for biotechnological applications. [GRAPHICS] .
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