Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 22, Issue 8, Pages 762-773Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2019.1642329
Keywords
Coxsackievirus B3; luteolin; antiviral activity; inflammation
Funding
- National Natural Science Foundation of China [81803592, 81503118]
- CAMS Initiative for Innovative Medicine [CAMS-I2M-1-010]
- National Science and Technology Major Projects for Major New Drugs Innovation and Development [2018ZX09711003]
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Coxsackievirus B3 (CVB3) infection causes many inflammation-related diseases, such as viral myocarditis and aseptic meningitis. However, no vaccines or drugs have been approved for prevention or therapy of CVB3-induced diseases. In this study, luteolin (3,4,5,7-tetrahydroxyflavone) had been found that could dose-dependently reduce the production of viral progeny and synthesis of CVB3 RNA and protein. The luteolin-mediated inhibition of CVB3 was found to be mechanistically possible, at least in part, through depressing the phosphorylation of p38 MAPK and JNK MAPK, and inhibiting NF-kappa B nuclear translocation and subsequently attenuated the expression of inflammatory cytokines in CVB3-infected cells. Luteolin may be a potential agent or supplement against CVB3 infection by inhibiting inflammation. [GRAPHICS] .
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