Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 22, Issue 8, Pages 724-731Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2019.1621851
Keywords
Kopsia officinalis; Apocynaceae; alkaloids; cytotoxicity
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Three new monoterpenoid indole alkaloids, kopsiaofficines A-D (1-3), were isolated from the 95% EtOH extract of the aerial parts of Kopsia officinalis. Their structures were established on the basis of spectroscopic data. The isolated alkaloids were tested in vitro for cytotoxic activity against seven lung cancer cell lines. Consequently, alkaloids 1 and 3 exhibited some cytotoxic activities against all the tested tumor cell lines with IC50 values less than 20 mu M.
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