Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 68, Issue 4, Pages 1667-1675Publisher
IOS PRESS
DOI: 10.3233/JAD-181218
Keywords
AHSG; alzheimer's disease; APP23 mice; hypoperfusion; inflammation; ITIH4
Categories
Funding
- Japan Agency for Medical Research and development (AMED) [7211700176, 7211700180, 7211700095]
- Otsuka Toshimi Scholarship Foundation [18-235]
- [17H0419619]
- [15K0931607]
- [17K1082709]
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Alzheimer's disease (AD) is the most common dementia and a progressive neurodegenerative disorder aggravated by chronic hypoperfusion (HP). Since numerous evidence suggests that inflammation is related with AD pathology, we investigated the expression change of two anti-inflammatory markers, inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) and alpha-2-HS-glycoprotein (AHSG), in a novel AD model (APP23) with HP at 12 month of age. As compared with wild type (WT, n = 10), immunohistochemical analysis showed a higher ITIH4 and a lower AHSG expressions in the cerebral cortex, hippocampus, and thalamus of the APP23 + HP group (n = 12) than the simple APP23 (n =10) group (*p < 0.05 and **p < 0.01 versus WT; (#)p < 0.05 and (##)p < 0.01 versus APP23). The present study provides an upregulation of anti-inflammatory ITIH4 and a downregulation of pro-inflammatory TNF alpha-dependent AHSG in a novel AD plus HP mice model.
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