Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 67, Issue 25, Pages 7073-7081Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.9b02663
Keywords
calcium; estrous cycle irregularity; subfertility; BAT thermogenesis; WAT browning; HFD-fed mice
Funding
- National Natural Science Foundation of China [31790411, 31672508, 31372397]
- National Key Research and Development Program of China [2016YFD0500503, 2017YFD0500501]
- Guangdong special support program [2014TQ01N260]
- Innovation team project in universities of Guangdong Province [2017KCXTD002]
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Obesity has been demonstrated as a disruptor of female fertility. Our previous study showed the antiobesity effects of calcium on HFD-fed male mice. However, the role of calcium in alleviating reproductive dysfunction of HFD-fed female mice remains unclear. Here, we found that HFD led to estrus cycle irregularity (longer cycle duration and shorter estrus period) and subfertility (longer conception time, lower fertility index, and less implantations) in mice. However, the HFD-induced reproductive abnormality was alleviated by calcium supplementation. Additionally, calcium supplementation enhanced activation/thermogenesis of BAT and browning of WAT in HFD-fed mice. Consequently, the abnormality of energy metabolism and glucose homeostasis induced by HFD were improved by calcium supplementation, with elevated metabolic rates and core temperature. In conclusion, these data showed that calcium supplementation alleviated HFD-induced estrous cycle irregularity and subfertility associated with concomitantly enhanced BAT thermogenesis and WAT browning, suggesting the potential application of calcium in improving obesity-related reproductive disorders.
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