Journal
INTERNATIONAL JOURNAL OF NANOMEDICINE
Volume 14, Issue -, Pages 5729-5749Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S210116
Keywords
tumor microenvironment; smart nanomedicine agents; theranostic agents; smart nanoprobes; smart nanocarriers
Funding
- National Natural Science Foundation of China [21601124, 21671135, 21701111]
- Shanghai Sailing Program [17YF1413700]
- Ministry of Education of China [PCSIRT_IRT_16R49]
- International Joint Laboratory on Resource Chemistry
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Effective tumor diagnosis and therapy have always been a significant but challenging issue. Although nanomedicine has shown great potential for improving the outcomes of tumor diagnosis and therapy, the nonspecial targeted distribution of nanomedicine agents in the whole body causes a low diagnosis signal-to-noise ratio and a potential risk of systemic toxicity. Recently, the development of smart nanomedicine agents with diagnosis and therapy functions that can only be activated by the tumor microenvironment (TME) is regarded as an effective strategy to improve the theranostic sensitivity and selectivity, as well as reduce the potential side effects during treatment. This article will introduce and summarize the latest achievements in the design and fabrication of TME-responsive smart nanomedicine agents, and highlight their prospects for enhancing tumor diagnosis and therapy.
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