Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 20, Issue 13, Pages -Publisher
MDPI
DOI: 10.3390/ijms20133276
Keywords
lncRNA; long non-coding RNA; miRNA; kidney; glomerulus; podocyte; acute kidney injury; AKI; diabetic nephropathy
Funding
- Nachwuchsgruppen.NRW program of the Ministry of Science North Rhine Westfalia (MIWF)
- German Research Foundation [KFO329, MU3629/3-1]
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Non-coding RNA species contribute more than 90% of all transcripts and have gained increasing attention in the last decade. One of the most recent members of this group are long non-coding RNAs (lncRNAs) which are characterized by a length of more than 200 nucleotides and a lack of coding potential. However, in contrast to this simple definition, lncRNAs are heterogenous regarding their molecular function-including the modulation of small RNA and protein function, guidance of epigenetic modifications and a role as enhancer RNAs. Furthermore, they show a highly tissue-specific expression pattern. These aspects already point towards an important role in cellular biology and imply lncRNAs as players in development, health and disease. This view has been confirmed by numerous publications from different fields in the last years and has raised the question as to whether lncRNAs may be future therapeutic targets in human disease. Here, we provide a concise overview of the current knowledge on lncRNAs in both glomerular and tubulointerstitial kidney disease.
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