Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 20, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/ijms20122940
Keywords
collagen deposition; diagnostic biomarkers; oral submucous fibrosis (OSF); precancerous disorder; therapeutic interventions; underlying mechanisms
Funding
- China Medical University, Taiwan [CMU107-S-37]
- Ministry of Science and Technology, Taiwan [MOST 106-2314-B-039-003-MY2, MOST 107-2314-B-468 -007]
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Oral submucous fibrosis (OSF) is characterized by abnormal collagen deposition. It is a precancerous disorder and transforms into a malignant tumor in 1.5-15% of all cases. Symptoms include submucous fibrosis, ulceration, xerostomia, a burning sensation, and restricted mouth opening. All of these greatly interfere with patient quality of life. The present review introduces OSF from a molecular perspective and summarizes what is known about its underlying mechanisms, diagnostic biomarkers, and therapeutic interventions. In addition to the aggressive treatment of OSF, its prevention is also important. Future research should, therefore, focus on improving the oral health literacy of the patients susceptible to OSF.
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