Journal
INORGANIC CHEMISTRY
Volume 58, Issue 20, Pages 13546-13560Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.inorgchem.9b01221
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Funding
- NIH [GM 79465]
- Life Sciences Research Foundation - Howard Hughes Medical Institute
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The complex network of chemical processes that sustain life motivates the development of new synthetic tools to decipher biological mechanisms of action at a molecular level. In this context, fluorescent and related optical probes have emerged as useful chemical reagents for monitoring small-molecule and metal signals in biological systems, enabling visualization of dynamic cellular events with spatial and temporal resolution. In particular, metals occupy a central role in this field as analytes in their own right, while also being leveraged for their unique biocompatible reactivity with small-molecule substrates. This Viewpoint highlights the use of inorganic chemistry principles to develop activity-based sensing platforms mediated by metal reactivity, spanning indicators for metal detection to metal-based reagents for bioorthogonal tracking, and manipulation of small and large biomolecules, illustrating the privileged roles of metals at the interface of chemistry and biology.
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