Journal
FUTURE MEDICINAL CHEMISTRY
Volume 11, Issue 12, Pages 1461-1483Publisher
FUTURE SCI LTD
DOI: 10.4155/fmc-2018-0608
Keywords
chelating ligands; contrast agents; MRI; manganese; relaxometry
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Funding
- Universita del Piemonte Orientale (Ricerca locale 2016)
- Ministerio de Economia y Competitividad [CTQ201676756-P]
- Xunta de Galicia [ED431B 2017/59, ED431D 2017/01]
- COST [CA15209]
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Mn(II) has several favorable physicochemical characteristics and a good toxicity profile, which makes it a viable alternative to the Gd(III)-based MRI contrast agents currently used in clinics. Although many studies have been undertaken in the last 10 years, this is a field of investigation still in rapid and continuous development. This review aims to critically discuss the chemical and magnetic properties of Mn(II) compounds relevant as MRI probes, both small complexes and nanosystems containing a large number of metal centers, the possible approaches for optimizing their efficiency by understanding the role of various molecular parameters that control the relaxation processes, and the most important issues related to stability and kinetic inertness.
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