Journal
FOOD RESEARCH INTERNATIONAL
Volume 120, Issue -, Pages 130-140Publisher
ELSEVIER
DOI: 10.1016/j.foodres.2019.02.024
Keywords
Bioactive compounds; Intestine-specific delivery; Encapsulation; Intestinal; Barriers; Digestion absorption models; Bioaccessibility; Bioavailability
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Funding
- Ministry of Science and Technology of China [2016YFD0400804]
- National Natural Science Foundation of China [NSFC 31471577, 31772014]
- Beijing Nova Program [Z181100006218071]
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Food-sourced bioactive compounds have drawn much attention due to their health benefits such as anti-oxidant, anti-cancer, anti-diabetes and cardiovascular disease-preventing functions. However, the poor solubility, low stability and limited bioavailability of sensitive bioactive compounds greatly limited their application in food industry. Therefore, numbers of carriers were developed for improving their dispersibility, stability and bioavailability. This review addresses the digestion and absorption mechanisms of bioactive compounds in epithelial cells based on several well-known in vitro and in vivo models. Factors such as environmental stimuli, stomach conditions and mucus barrier influencing the utilization efficacy of the bioactive compounds are discussed. Delivery systems with enhanced utilization efficacy, such as complex coacervates, cross-linked polysaccharides, self-assembled micro-/nano-particles and Pickering emulsions are compared. It is a comprehensive multidisciplinary review which provides useful guidelines for application of bioactive compounds in food industry.
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