Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 129, Issue -, Pages 354-364Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2019.05.007
Keywords
Apricot kernel skin; Polyphenols; Antioxidant; Antibacterial; HepG2 cells
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Funding
- National Natural Science Foundation of China [21606181, 21675125]
- Shaanxi Key Research and Development Program [2018ZDXM-NY-087]
- Science and Technology Huimin Plan of China [2012GS610203]
- Amygdalus pedunculata Engineering Technology Research Center of State Forestry Administration
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The polyphenols profiles of the methanol extracts of bitter apricot [Armeniaca Sibirica (L.)] kernel skins (AKS) were analysed by liquid chromatography-electrospray ionization mass spectrometry. The antioxidan, anticancer effect on HepG2 cell and antibacterial properties of the AKS polyphenol extracts were further characterized in vitro. Polyphenol compounds (35), including nine phenolic acids, thirteen anthocyanins and thirteen flavonoids, were identified in AKS for the first time. The content of apigenin 7-O-glucoside, (cyanidin 3-(4 ''-acetylrutinoside), 3- (6 ''-acetylglucoside)-5-glucoside and salicylic acid was relatively high than the others. The AKS poly phenols strongly reduced Fe3+ and exhibited good scavenging activity towards 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) free radicals, 1,1-diphenyl-1-picrylhydrazyl free radicals, hydroxyl radicals, superoxide anions and hydrogen peroxide. The AKS polyphenols could regulate oxidant stress in HepG2 cells by downregulating reduced glutathione, upregulating oxidative glutathione, malondialdehyde and advanced oxidation protein products, and reduced cell viability to induce apoptosis of HepG2 cells in vitro. The AKS poly phenols showed strong antibacterial activity against Escherichia colt, Staphylococcus aureus, Bacillus subtilis, Acetobacter aceti and Bacillus cereus. Therefore, the antioxidant, inhibitory effect on HepG2 cells and antimicrobial activity of the AKS polyphenols were distinct and worthy of further consideration for medical industry applications.
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