Journal
FITOTERAPIA
Volume 135, Issue -, Pages 114-129Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2019.04.012
Keywords
Chromone; Antitumor activity; Mechanism; Cytotoxicity
Categories
Funding
- Program for National Natural Science Foundation of China [81803687]
- Fundamental Research Funds for the Central Universities [2018-JYBZZ-XJSJJ007]
- Beijing Municipal Natural Science Foundation [7192117]
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Chromones are a group of compounds widely distributed in nature with wide range of biological activities, including antitumor, antimicrobial, antiviral, anti-inflammatory, antioxidant, and so on. This review mainly summarizes chromones with antitumor activity in nature and classifies them into three groups, including chromanones, simple chromones, and fused chromones. They exhibit antitumor activity through broad range of mechanisms including cytotoxicity, antimetastasis, antiangiogenesis, chemoprevention, immune regulation, etc.
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