Journal
FISH & SHELLFISH IMMUNOLOGY
Volume 90, Issue -, Pages 308-316Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fsi.2019.04.304
Keywords
Takifugu rubripes; Vibrio harveyi; Transcriptome analysis; Differentially expressed genes; Immune response
Funding
- National Natural Science Foundation of China [31702336]
- Doctoral Start-up Foundation of Liaoning Province [20170520172]
- China Agricultural Research System [CARS-47]
- Public Science and Technology Research Funds Projects of Ocean of State Oceanic Administration People's Republic of China [201405003]
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Japanese pufferfish (Takifugu rubripes) is one of the main marine aquatic fish species cultured in Asia due to its high nutritional value. In recent years, disease caused by Vibrio harveyi infections have led to serious mortality in Japanese pufferfish industry. To understand the complex molecular mechanisms between V. harveyi and Japanese pufferfish, we performed a transcriptome analysis of liver and spleen samples from Japanese pufferfish at 1 and 2 day post-infection. Between-group comparisons revealed 922 genes that were significantly differentially expressed. The altered genes emphasized the function in several immune related pathways including MAPK signaling pathway, JAK-STAT signaling pathway, toll-like receptor signaling pathway, cytokine-cytokine receptor interaction and lysosomal pathway. The data generated in this study provided insight into the responses of Japanese pufferfish against V. harveyi at the transcriptome level, promoting our comprehensive understanding of immune responses for aquatic animal against V. harveyi.
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