Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2019, Issue 28, Pages 4617-4623Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201900831
Keywords
Nitriles; Oxime esters; Iron; Co-Catalysis; Synthetic methods
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A mild, scalable, high yielding, and rapid route to access diverse nitriles from aldehyde oxime esters enabled by iron(III) and phenol co-catalysis has been developed. The reaction was performed at room temperature to give nitriles in excellent yield within minutes. Mechanistic studies show that the reaction may proceed through a radical process in which benzoyl aldehyde oxime is not only a substrate, but also an ancillary ligand to support iron salt in the promotion of the transformation.
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