Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 173, Issue -, Pages 117-153Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2019.03.063
Keywords
Synthesis; Chlorinated compounds; Biological applications; SAR
Categories
Funding
- National Natural Science Foundation of China [21772150]
- Wuhan applied fundamental research plan of Wuhan Science and Technology Bureau [2017060201010216]
- Wuhan University of Technology
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At present more than 250 FDA approved chlorine containing drugs were available in the market and many pharmaceutically important drug candidates in pre-clinical trials. Thus, it is quite obvious to expect that in coming decades there will be an even greater number of new chlorine-containing pharmaceuticals in market. Chlorinated compounds represent the family of compounds promising for use in medicinal chemistry. This review describes the recent advances in the synthesis of chlorine containing heterocyclic compounds as diverse biological agents and drugs in the pharmaceutical industries for the inspiration of the discovery and development of more potent and effective chlorinated drugs against numerous death-causing diseases. (C) 2019 Elsevier Masson SAS. All rights reserved.
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