Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 174, Issue -, Pages 277-291Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2019.04.054
Keywords
AIDS; HIV-1; NNRTIs; Entrance channel; Diarylpyrimidines
Categories
Funding
- National Natural Science Foundation of China [21877087, 21602164, 21807082, 21402148]
- Wuhan International Scientific and Technological Cooperation Project [2017030209020257]
- Natural Science Foundation of Hubei Province of China [2017CFB121]
- Hubei Provincial Department of Education of China [Q20171503]
- Wuhan Institute of Technology Scientific Research Fund [K201716]
- Wuhan Institute of Technology Graduate Innovation Fund [CX2017117]
Ask authors/readers for more resources
Since the entrance channel was proposed as a new binding site in non-nucleoside reverse transcriptase inhibitor binding pocket (NNIBP) of HIV-1 reverse transcriptase (RT) in 2012, a huge number of HIV-1 inhibitors acting on this target have sprung up, aiming to discover promising inhibitors with excellent antiviral activities, physicochemical properties, and so on. From 2012 to 2018, many noteworthy compounds have been continuously discovered. In this review, the recent progress in HIV-1 inhibitors targeting the entrance channel of HIV-1 NNIBP was summarized and reviewed, which would provide useful clues and inspiration for further design of HIV-1 inhibitors. (C) 2019 Elsevier Masson SAS. All rights reserved.
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