Journal
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
Volume 2019, Issue 29, Pages 3354-3365Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejic.201900387
Keywords
Magnetic resonance imaging; Photoacoustic imaging; Gadolinium; Chelates; Macrocyclic ligands
Categories
Funding
- FNRS
- ARC
- Walloon Region (Gadolymph project)
- Interuniversity Attraction Poles of the Belgian Federal Science Policy Office
- COST actions
- FEDER
- Walloon Region (Holocancer project)
- Walloon Region (Interreg project)
- European Regional Development Fund Wallonia
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One of the most widely used techniques to obtain anatomical information is magnetic resonance imaging (MRI). Despite its high resolution, it has a low sensitivity which could be enhanced by coupling MRI with a more sensitive technique such as photoacoustic imaging (PAI). The development of a bimodal agent could thus lead to hybrid images with a high anatomical resolution provided by MRI and a precise localization of the contrast agent thanks to PAI. The probes used in this work are a gadolinium(III) complex derived from PCTA-[12] for MRI and the ZW800-1 fluorophore for PAI. These two organic parts have been attached to a L-lysine derivative which has a third site for potential conjugation to a biovector, thus opening the field of targeted probes for molecular imaging. Preliminary relaxometric and photoacoustic characterizations indicate that this bimodal agent is a promising compound for bimodal imaging.
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