Journal
EMBO JOURNAL
Volume 38, Issue 16, Pages -Publisher
WILEY
DOI: 10.15252/embj.2018100836
Keywords
circRNAs; circular RNAs; non-coding RNAs; RNA processing; splicing
Categories
Funding
- NIH [R01GM122406, R01AG057700]
- Alexander von Humboldt Foundation through Feodor Lynen Research Fellowship
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Exonic circular RNAs (circRNAs) are covalently closed RNA molecules generated by a process named back-splicing. circRNAs are highly abundant in eukaryotes, and many of them are evolutionary conserved. In metazoans, circular RNAs are expressed in a tissue-specific manner, are highly stable, and accumulate with age in neural tissues. circRNA biogenesis can regulate the production of the linear RNA counterpart in cis as back-splicing competes with linear splicing. Recent reports also demonstrate functions for some circRNAs in trans: Certain circRNAs interact with microRNAs, some are translated, and circRNAs have been shown to regulate immune responses and behavior. Here, we review current knowledge about animal circRNAs and summarize new insights into potential circRNA functions, concepts of their origin, and possible future directions in the field.
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