Related references
Note: Only part of the references are listed.Exploiting the genome sequence of Streptomyces nodosus for enhanced antibiotic production
Paul Sweeney et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2016)
Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation
Jesus F. Aparicio et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2016)
Substrate structure-activity relationships guide rational engineering of modular polyketide synthase ketoreductases
Constance B. Bailey et al.
CHEMICAL COMMUNICATIONS (2016)
Using Genomics for Natural Product Structure Elucidation
Jonathan I. Tietz et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2016)
Predictive Bioinformatic Assignment of Methyl-Bearing Stereocenters, Total Synthesis, and an Additional Molecular Target of Ajudazol B
Sebastian Essig et al.
JOURNAL OF ORGANIC CHEMISTRY (2016)
Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against Trypanosoma brucei
Christopher J. Schulze et al.
ACS CHEMICAL BIOLOGY (2015)
被撤回的出版物: Genome sequence and genome mining of a marine-derived antifungal bacterium Streptomyces sp M10 (Retracted article. See vol. 100, pg. 519, 2016)
Jingbo Tang et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2015)
Engineered biosynthesis of pimaricin derivatives with improved antifungal activity and reduced cytotoxicity
Zhen Qi et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2015)
Taming Amphotericin B
Vadav Janout et al.
BIOCONJUGATE CHEMISTRY (2015)
Role of polyol moiety of amphotericin B in ion channel formation and sterol selectivity in bilayer membrane
Tomoya Yamamoto et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2015)
Evaluating Ketoreductase Exchanges as a Means of Rationally Altering Polyketide Stereochemistry
Thibault Annaval et al.
CHEMBIOCHEM (2015)
The stereostructure of candicidin D
Katarzyna Szwarc et al.
JOURNAL OF ANTIBIOTICS (2015)
Functional manipulations of the tetramycin positive regulatory gene ttmRIV to enhance the production of tetramycin A and nystatin A1 in Streptomyces ahygroscopicus
Hao Cui et al.
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2015)
Restored Physiology in Protein-Deficient Yeast by a Small Molecule Channel
Alexander G. Cioffi et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)
The structure, including stereochemistry, of levorin A1
Katarzyna Szwarc et al.
MAGNETIC RESONANCE IN CHEMISTRY (2015)
Generation of the natamycin analogs by gene engineering of natamycin biosynthetic genes in Streptomyces chattanoogensis L10
Shui-Ping Liu et al.
MICROBIOLOGICAL RESEARCH (2015)
Production of the antibiotic FR-008/candicidin in Streptomyces sp FR-008 is co-regulated by two regulators, FscRI and FscRIV, from different transcription factor families
Peipei Zhang et al.
MICROBIOLOGY-SGM (2015)
Nontoxic antimicrobials that evade drug resistance
Stephen A. Davis et al.
NATURE CHEMICAL BIOLOGY (2015)
New Rimocidin/CE-108 Derivatives Obtained by a Crotonyl-CoA Carboxylase/Reductase Gene Disruption in Streptomyces diastaticus var. 108: Substrates for the Polyene Carboxamide Synthase PcsA
Leticia Escudero et al.
PLOS ONE (2015)
IFITM Proteins Restrict HIV-1 Infection by Antagonizing the Envelope Glycoprotein
Jingyou Yu et al.
CELL REPORTS (2015)
Exploration of the Substrate Promiscuity of Biosynthetic Tailoring Enzymes as a New Source of Structural Diversity for Polyene Macrolide Antifungals
Javier Santos-Aberturas et al.
CHEMCATCHEM (2015)
Post-PKS Tailoring Steps of a Disaccharide-Containing Polyene NPP in Pseudonocardia autotrophica
Hye-Jin Kim et al.
PLOS ONE (2015)
Functional analysis of filipin tailoring genes from Streptomyces filipinensis reveals alternative routes in filipin III biosynthesis and yields bioactive derivatives
Tamara D. Payero et al.
MICROBIAL CELL FACTORIES (2015)
Genome scanning inspired isolation of reedsmycins A-F, polyene-polyol macrolides from Streptomyces sp CHQ-64
Qian Che et al.
RSC ADVANCES (2015)
In Vitro Synergistic Effect of Amphotericin B and Allicin on Leishmania donovani and L. infantum
M. J. Corral et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)
Balance between Exocytosis and Endocytosis Determines the Efficacy of Sterol-Targeting Antibiotics
Shinichi Nishimura et al.
CHEMISTRY & BIOLOGY (2014)
Reactive oxygen species-inducing antifungal agents and their activity against fungal biofilms
Nicolas Delattin et al.
FUTURE MEDICINAL CHEMISTRY (2014)
Efficacy of low doses of amphotericin B plus allicin against experimental visceral leishmaniasis
M. Jesus Corral et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2014)
Amphotericin forms an extramembranous and fungicidal sterol sponge
Thomas M. Anderson et al.
NATURE CHEMICAL BIOLOGY (2014)
Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development
Chris J. Paddon et al.
NATURE REVIEWS MICROBIOLOGY (2014)
Filipins: the first antifungal weed killers identified from bacteria isolated from the trap-ant
Hong Gao et al.
RSC ADVANCES (2014)
Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074
Carlos Olano et al.
MICROBIAL BIOTECHNOLOGY (2014)
Structural Studies of an A2-Type Modular Polyketide Synthase Ketoreductase Reveal Features Controlling α-Substituent Stereochemistry
Jianting Zheng et al.
ACS CHEMICAL BIOLOGY (2013)
Structure-Antifungal Activity Relationships of Polyene Antibiotics of the Amphotericin B Group
Anna N. Tevyashova et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2013)
Improvement of Natamycin Production by Engineering of Phosphopantetheinyl Transferases in Streptomyces chattanoogensis L10
Hui Jiang et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2013)
Engineered Biosynthesis of Disaccharide-Modified Polyene Macrolides
Eimear De Poire et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2013)
Versatility of Enzymes Catalyzing Late Steps in Polyene 67-121C Biosynthesis
Niamh Stephens et al.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2013)
Active Site Comparisons and Catalytic Mechanisms of the Hot Dog Superfamily
Jason W. Labonte et al.
CHEMICAL REVIEWS (2013)
Structural and Stereochemical Analysis of a Modular Polyketide Synthase Ketoreductase Domain Required for the Generation of a cis-Alkene
Shilah A. Bonnett et al.
CHEMISTRY & BIOLOGY (2013)
Biosynthesis and pathway engineering of antifungal polyene macrolides in actinomycetes
Dekun Kong et al.
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2013)
C2′-OH of Amphotericin B Plays an Important Role in Binding the Primary Sterol of Human Cells but Not Yeast Cells
Brandon C. Wilcock et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
In vivo investigation of the substrate recognition capability and activity affecting amino acid residues of glycosyltransferase FscMI in the biosynthesis of candicidin
Xuan Lei et al.
MOLECULAR BIOSYSTEMS (2013)
Amphotericin B Increases Influenza A Virus Infection by Preventing IFITM3-Mediated Restriction
Tsai-Yu Lin et al.
CELL REPORTS (2013)
Fitness Trade-offs Restrict the Evolution of Resistance to Amphotericin B
Benjamin Matteson Vincent et al.
PLOS BIOLOGY (2013)
Structural analysis and biosynthetic engineering of a solubility-improved and less-hemolytic nystatin-like polyene in Pseudonocardia autotrophica
Mi-Jin Lee et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2012)
Streptomyces nodosus Host Strains Optimized for Polyene Glycosylation Engineering
Niamh Stephens et al.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2012)
Genome Mining of the Biosynthetic Gene Cluster of the Polyene Macrolide Antibiotic Tetramycin and Characterization of a P450 Monooxygenase Involved in the Hydroxylation of the Tetramycin B Polyol Segment
Bo Cao et al.
CHEMBIOCHEM (2012)
Bahamaolides A and B, Antifungal Polyene Polyol Macrolides from the Marine Actinomycete Streptomyces sp.
Dong-Gyu Kim et al.
JOURNAL OF NATURAL PRODUCTS (2012)
Amphotericin primarily kills yeast by simply binding ergosterol
Kaitlyn C. Gray et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Stereoselectivity of Isolated Dehydratase Domains of the Borrelidin Polyketide Synthase: Implications for cis Double Bond Formation
Olivia Vergnolle et al.
CHEMBIOCHEM (2011)
Draft Genome Sequence of Streptomyces Strain S4, a Symbiont of the Leaf-Cutting Ant Acromyrmex octospinosus
Ryan F. Seipke et al.
JOURNAL OF BACTERIOLOGY (2011)
Antimycotic-Antibiotic Amphotericin B Promotes Influenza Virus Replication in Cell Culture
Elisabeth Roethl et al.
JOURNAL OF VIROLOGY (2011)
Probing the Role of the Mycosamine C2′-OH on the Activity of Amphotericin B
Mitchell P. Croatt et al.
ORGANIC LETTERS (2011)
A Single Streptomyces Symbiont Makes Multiple Antifungals to Support the Fungus Farming Ant Acromyrmex octospinosus
Ryan F. Seipke et al.
PLOS ONE (2011)
The pcsA gene from Streptomyces diastaticus var. 108 encodes a polyene carboxamide synthase with broad substrate specificity for polyene amides biosynthesis
Elena M. Seco et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2010)
A mixed community of actinomycetes produce multiple antibiotics for the fungus farming ant Acromyrmex octospinosus
Joerg Barke et al.
BMC BIOLOGY (2010)
Structure of Cytochrome P450 PimD Suggests Epoxidation of the Polyene Macrolide Pimaricin Occurs via a Hydroperoxoferric Intermediate
Petrea M. Kells et al.
CHEMISTRY & BIOLOGY (2010)
Redesign of Polyene Macrolide Glycosylation: Engineered Biosynthesis of 19-(O)-Perosaminyl-Amphoteronolide B
Eve Hutchinson et al.
CHEMISTRY & BIOLOGY (2010)
Synthesis and study of the antifungal activity of new mono- and disubstituted derivatives of a genetically engineered polyene antibiotic 28,29-didehydronystatin A1 (S44HP)
Maria N. Preobrazhenskaya et al.
JOURNAL OF ANTIBIOTICS (2010)
Isolation and characterisation of amphotericin B analogues and truncated polyketide intermediates produced by genetic engineering of Streptomyces nodosus
Barry Murphy et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2010)
Tailoring the P450 Monooxygenase Gene for FR-008/Candicidin Biosynthesis
Shi Chen et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2009)
Candicidin Biosynthesis Gene Cluster Is Widely Distributed among Streptomyces spp. Isolated from the Sediments and the Neuston Layer of the Trondheim Fjord, Norway
Hanne Jorgensen et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2009)
Discovery of a pimaricin analog JBIR-13, from Streptomyces bicolor NBRC 12746 as predicted by sequence analysis of type I polyketide synthase gene
Hisayuki Komaki et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2009)
Amphotericin B interactions with soluble oligomers of amyloid Aβ1-42 peptide
Nicholas W. Smith et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
Biosynthesis of Macrolactam BE-14106 Involves Two Distinct PKS Systems and Amino Acid Processing Enzymes for Generation of the Aminoacyl Starter Unit
Hanne Jorgensen et al.
CHEMISTRY & BIOLOGY (2009)
The structural basis for catalytic function of GMD and RMD, two closely related enzymes from the GDP-d-rhamnose biosynthesis pathway
Jerry D. King et al.
FEBS JOURNAL (2009)
The vacuole-targeting fungicidal activity of amphotericin B against the pathogenic fungus Candida albicans and its enhancement by allicin
Hasibagan Borjihan et al.
JOURNAL OF ANTIBIOTICS (2009)
Identification of functionally clustered nystatin-like biosynthetic genes in a rare actinomycetes, Pseudonocardia autotrophica
Byung-Gyun Kim et al.
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY (2009)
Marinisporolides, Polyene-Polyol Macrolides from a Marine Actinomycete of the New Genus Marinispora
Hak Cheol Kwon et al.
JOURNAL OF ORGANIC CHEMISTRY (2009)
The Biochemical Basis for Stereochemical Control in Polyketide Biosynthesis
Chiara R. Valenzano et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Phosphomannose isomerase and phosphomannomutase gene disruptions in Streptomyces nodosus: Impact on amphotericin biosynthesis and implications for glycosylation engineering
Laura Nic Lochlainn et al.
METABOLIC ENGINEERING (2009)
Structurally diverse natural products that cause potassium leakage trigger multicellularity in Bacillus subtilis
Daniel Lopez et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Candicidin-producing Streptomyces support leaf-cutting ants to protect their fungus garden against the pathogenic fungus Escovopsis
Susanne Haeder et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Synthesis of 35-deoxy amphotericin B methyl ester: A strategy for molecular editing
Alex M. Szpilman et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)
The in vitro Characterization of Polyene Glycosyltransferases AmphDI and NysDI
Changsheng Zhang et al.
CHEMBIOCHEM (2008)
Prediction and Manipulation of the Stereochemistry of Enoylreduction in Modular Polyketide Synthases
David H. Kwan et al.
CHEMISTRY & BIOLOGY (2008)
Improved Antifungal Polyene Macrolides via Engineering of the Nystatin Biosynthetic Genes in Streptomyces noursei
Trygve Brautaset et al.
CHEMISTRY & BIOLOGY (2008)
Biosynthetic engineering of polyene macrolides towards generation of improved antifungal and antiparasitic agents
Patrick Caffrey et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2008)
cis-Δ2,3-double bond of phoslactomycins is generated by a post-PKS tailoring enzyme
Nadaraj Palaniappan et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Engineered biosynthesis of hybrid macrolide polyketides containing D-angolosamine and D-mycaminose moieties
Ursula Schell et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2008)
A Post-PKS oxidation of the amphotericin B skeleton predicted to be critical for channel formation is not required for potent antifungal activity
Daniel S. Palacios et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Analysis of the mycosamine biosynthesis and attachment genes in the nystatin Biosynthetic gene cluster of Streptomyces noursei ATCC 11455
Aina Nedal et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2007)
A tylosin ketoreductase reveals how chirality is determined in polyketides
Adrian T. Keatinge-Clay
CHEMISTRY & BIOLOGY (2007)
Cholesterol oxidases act as signaling proteins for the biosynthesis of the polyene macrolide pimaricin
Marta V. Mendes et al.
CHEMISTRY & BIOLOGY (2007)
Modular polyketide synthases and cis double bond formation:: Establishment of activated cis-3-cyclohexylpropenoic acid as the diketide intermediate in phoslactomycin biosynthesis
Mamoun M. Alhamadsheh et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Use of cyclodextrins to manipulate plasma membrane cholesterol content: Evidence, misconceptions and control strategies
Raphael Zidovetzki et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2007)
Selective activity of polyene macrolides produced by genetically modified Streptomyces on Trypanosoma cruzi
Miriam Rolon et al.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2006)
Biosynthetic pathway for mannopeptimycins, lipoglycopeptide antibiotics active against drug-resistant gram-positive pathogens
Nathan A. Magarvey et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2006)
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
DK Ro et al.
NATURE (2006)
Characterization of the P450 monooxygenase NysL, responsible for C-10 hydroxylation during biosynthesis of the polyene macrolide antibiotic nystatin in Streptomyces noursei
O Volokhan et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2006)
Identification and analysis of the chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium cellulosum So ce56
O Perlova et al.
JOURNAL OF BIOTECHNOLOGY (2006)
Nystatin biosynthesis and transport:: nysH and nysG genes encoding a putative ABC transporter system in Streptomyces noursei ATCC 11455 are required for efficient conversion of 10-deoxynystatin to nystatin
H Sletta et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2005)
Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups
M Carmody et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Molecular basis of Celmer's rules: Stereochemistry of catalysis by isolated ketoreductase domains from modular polyketide synthases
AP Siskos et al.
CHEMISTRY & BIOLOGY (2005)
Amphotericin B
A Lemke et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2005)
Chemical diversity of polyene macrolides produced by Streptomyces noursei ATCC 11455 and recombinant strain ERD44 with genetically altered polyketide synthase NysC
P Bruheim et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2004)
PI factor, a novel type quorum-sensing inducer elicits pimaricin production in Streptomyces natalensis
E Recio et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Conserved amino acid residues correlating with ketoreductase stereospecificity in modular polyketicle synthases
P Caffrey
CHEMBIOCHEM (2003)
Amphotericin B binds to amyloid fibrils and delays their formation: A therapeutic mechanism?
SC Hartsel et al.
BIOCHEMISTRY (2003)
Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis
H Ikeda et al.
NATURE BIOTECHNOLOGY (2003)
A model of structure and catalysis for ketoreductase domains in modular polyketide synthases
R Reid et al.
BIOCHEMISTRY (2003)
Modification of post-PKS tailoring steps through combinatorial biosynthesis
U Rix et al.
NATURAL PRODUCT REPORTS (2002)
MFAME, N-methyl-N-D-fructosyl amphotericin B methyl ester, a new amphotericin B derivative of low toxicity:: relationship between self-association and effects on red blood cells
J Szlinder-Richert et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2001)
Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455:: analysis of the gene cluster and deduction of the biosynthetic pathway
T Brautaset et al.
CHEMISTRY & BIOLOGY (2000)