Journal
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Volume 100, Issue 20, Pages 8693-8699Publisher
SPRINGER
DOI: 10.1007/s00253-016-7829-5
Keywords
Nissle 1917; Genetic modification; Cryptic plasmids; Chromosome; Clinical application
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Funding
- Chinese National Science Foundation [30571374, 30771603, 31072136, 31270171]
- Genetically Modified Organisms Technology Major Project of China [2014ZX08006-001B]
- Jiangsu innovation research program for University postgraduate [KYLX15_1382]
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Escherichia coli strain Nissle 1917 (EcN) has been used as a probiotic. Genetic engineering has enhanced the utility of EcN in several vaccine and pharmaceutical preparations. We discuss in this mini review the genetics and physical properties of EcN. We also discuss the numerous genetic engineering strategies employed for EcN-based vaccine development, including recombinant plasmid transfer, genetic engineering of cryptic plasmids or the EcN chromosome, EcN bacterial ghosts and its outer membrane vesicles. We also provide a current update on the progress and the challenges regarding the use of EcN in vaccine development.
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