Journal
DYES AND PIGMENTS
Volume 166, Issue -, Pages 72-83Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2019.03.009
Keywords
NIR fluorescence imaging; Mitochondria-targeted; Photodynamic therapy, chemotherapy; Theranostic agent
Funding
- Natural Science Foundation of China [81360471, 81660575]
- Innovative Group Project of Guizhou Province of Education [KY [2018]024]
- Academic Seedling Program of Zunyi Medical University [[2017]5733-042]
- Doctor Foundation of Zunyi Medical University [F-862]
- Education department of Guizhou Province of China [GNYL [2017]006, YLXKJS-YS-06]
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In the fight against cancer, it is urgently necessary to design a single-molecular theranostic agent (SMTA) for simultaneous diagnosis and therapy. However, this goal has not been accomplished. Here, to achieve this ambition, a chemotherapy drug of the aromatic nitrogen mustard class is covalently conjugated onto a small molecule, rhodamine, as an SMTA for the first time. The SMTA can perform multiple functionalities, including mitochondrial-targeted delivery, near-infrared (NIR) fluorescence imaging, NIR photodynamic therapy, and chemotherapy. We verified the synergetic anti-cancer effect through both in vitro and in vivo experiments. Our SMTA may provide a new avenue to explore multiple-functionality anti-cancer agents in theranostics.
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