Journal
DYES AND PIGMENTS
Volume 166, Issue -, Pages 211-216Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2019.03.012
Keywords
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Funding
- NSFC [21722101, 21527801, 21671042, 21701109]
- National Key R&D Program of China [2017YFA0205100]
- MOST of China [2015CB931800]
- National Basic Research Program of China [2016YFA0201600]
- Shanghai Sci. Tech. Comm. [15QA1400700]
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A cyanine dye (Cy7) based turn-on fluorescence probe has been successfully synthesized for the detection of nitric oxide through the attachment of a methyl amino group at the meso position of Cy7 dye. The probe exhibits weak fluorescent emission at 800 nm due to intramolecular charge transfer process, while it quickly turns into highly NIR fluorescent state upon the treatment with NO. The detection limit is as low as 11.3 nM. In addition, the selectivity of the probe toward NO over reactive oxygen species, reactive nitrogen species, and metal ions was also demonstrated. Importantly, the fluorescence response of this probe to NO occurs in the physiologically favorable NIR region, enabling its further use to image endogenous NO in an inflamed mouse model with low background interference and deep penetration depth.
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