Journal
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
Volume 45, Issue 10, Pages 1590-1598Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/03639045.2019.1628250
Keywords
Meloxicam (MX); prodrug; meloxicam pivalate (MXP); rat model; and in-vivo taste assessment
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Funding
- UGC-BSR, India
- All India Council for Technical Education
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Meloxicam (MX), a nonsteroidal anti-inflammatory drug, widely used to treat arthritis, has a very bitter taste. Chemical modification of the bitter functionality was achieved by synthesis of a prodrug, meloxicam pivalate (MXP). Taste improvement was evaluated using single bottle-test rat model. It was found that palatability of MXP solution improved significantly as compared to MX.
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