Journal
DNA REPAIR
Volume 81, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.dnarep.2019.102662
Keywords
DNA double strand break repair; Homologous recombination; NHEJ; RNA; R-loops
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Funding
- Spanish Ministry of Economy and Competitivity [SAF2016-74855-P]
- European Union Regional Funds (FEDER)
- Spanish Ministry of Education
- regional government of Andalucia (Junta de Andalucia)
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DNA end resection is a critical step in the repair of DNA double strand breaks. It controls the way the lesion is going to be repaired, thus its regulation has a great importance in maintaining genomic stability. In this review, we focus in recent discoveries in the field that point to a modulation of resection by RNA molecules and RNA-related proteins. Moreover, we aim to reconcile contradictory reports on the positive or negative effect of DNA:RNA hybrids in the resection process.
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