Journal
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Volume 100, Issue 15, Pages 6545-6553Publisher
SPRINGER
DOI: 10.1007/s00253-016-7648-8
Keywords
Antibiotic tolerance; Antibiotic resistance; Persisters; Bet hedging; Antibiotic development; Bacterial infections
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Funding
- Estonian Research Council [IUT 2-22, PUT37]
- Swedish Research Council [2013-4680]
- Kempe Foundation
- Ragnar Soderberg Foundation
- European Regional Development Fund through the Center of Excellence in Molecular Cell Engineering
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Persisters-a drug-tolerant sub-population in an isogenic bacterial culture-have been featured throughout the last decade due to their important role in recurrent bacterial infections. Numerous investigations detail the mechanisms responsible for the formation of persisters and suggest exciting strategies for their eradication. In this review, we argue that the very term persistence is currently used to describe a large and heterogeneous set of physiological phenomena that are functions of bacterial species, strains, growth conditions, and antibiotics used in the experiments. We caution against the oversimplification of the mechanisms of persistence and urge for a more rigorous validation of the applicability of these mechanisms in each case.
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