Journal
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Volume 100, Issue 14, Pages 6165-6181Publisher
SPRINGER
DOI: 10.1007/s00253-016-7610-9
Keywords
Snake; Venom; Toxin; Therapeutic
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Funding
- Health and Medical Research Fund from the Food and Health Bureau [12131221]
- Hong Kong Special Administration Region Government from the National Natural Science Foundation of China, People's Republic of China [81201270, 81471927]
- Medicine Panel, Research Committee [4054049, 4054135]
- Chinese University of Hong Kong from the Science and Technology Innovation Commission of Shenzhen [JCYJ20150525092941055]
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Snake venoms are complex mixtures of small molecules and peptides/proteins, and most of them display certain kinds of bioactivities. They include neurotoxic, cytotoxic, cardiotoxic, myotoxic, and many different enzymatic activities. Snake envenomation is a significant health issue as millions of snakebites are reported annually. A large number of people are injured and die due to snake venom poisoning. However, several fatal snake venom toxins have found potential uses as diagnostic tools, therapeutic agent, or drug leads. In this review, different non-enzymatically active snake venom toxins which have potential therapeutic properties such as antitumor, antimicrobial, anticoagulating, and analgesic activities will be discussed.
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