Journal
DEVELOPMENT
Volume 146, Issue 13, Pages -Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.167502
Keywords
Development; Genetic loss of function; Retinoic acid; Signaling
Categories
Funding
- National Institutes of Health [R01 AR067731]
- Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Universite de Strasbourg, Agence Nationale de la Recherche [ANR-10-BLAN-1239, ANR-10-LABX-0030-INRT, 13-BSV6-0003, 13-BSV2-0017]
- Marie Curie Intra-European Fellowships for Career Development [FP7-PEOPLE-IEF-2012-331687]
- Agence Nationale de la Recherche (ANR) [ANR-10-BLAN-1239] Funding Source: Agence Nationale de la Recherche (ANR)
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Retinoic acid (RA), a metabolite of retinol (vitamin A), functions as a ligand for nuclear RA receptors (RARs) that regulate development of chordate animals. RA-RARs can activate or repress transcription of key developmental genes. Genetic studies in mouse and zebrafish embryos that are deficient in RA-generating enzymes or RARs have been instrumental in identifying RA functions, revealing that RA signaling regulates development of many organs and tissues, including the body axis, spinal cord, forelimbs, heart, eye and reproductive tract. An understanding of the normal functions of RA signaling during development will guide efforts for use of RA as a therapeutic agent to improve human health. Here, we provide an overview of RA signaling and highlight its key functions during development.
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