Journal
CURRENT PROTEIN & PEPTIDE SCIENCE
Volume 20, Issue 9, Pages 873-884Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389203720666190704152827
Keywords
ATP-diphosphohydrolase; apyrase; parasite; ATPDases; inhibitors; NTPDase; ecto-nucleotidases
Categories
Funding
- FAPEMIG [APQ 0171/11, APQ 02015/14, PPM-00296-16, BPD 00284-14]
- CNPq [487221/2012-5, PDJ 165878/2015-0, 478430/2013-2]
- CAPES
- PIBIC/CNPq/UFJF
- CNPq
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ATP-diphosphohydrolases (EC 3.6.1.5), also known as ATPDases, NTPases, NTPDases, E-ATPases or apyrases, are enzymes that hydrolyze a variety of nucleoside tri- and diphosphates to their respective nucleosides, being their activities dependent on the presence of divalent cations, such as calcium and magnesium. Recently, ATP-diphosphohydrolases were identified on the surface of several parasites, such as Trypanosoma sp, Leishmania sp and Schistosoma sp. In parasites, the activity of ATP-diphosphohydrolases has been associated with the purine recuperation and/or as a protective mechanism against the host organism under conditions that involve ATP or ADP, such as immune responses and platelet activation. These proteins have been suggested as possible targets for the development of new antiparasitic drugs. In this review, we will comprehensively address the main aspects of the location and function of ATP-diphosphohydrolase in parasites. Also, we performed a detailed research in scientific database of recent developments in new natural and synthetic inhibitors of the ATP-diphosphohydrolases in parasites.
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