Journal
CURRENT PROTEIN & PEPTIDE SCIENCE
Volume 20, Issue 9, Pages 885-892Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389203720666190626160057
Keywords
Tuberculosis; Mycobacterium tuberculosis; antimicrobial peptides; natural CAMPs; synthetic CAMPs
Categories
Funding
- FCT [PD/BD/135458/2017]
- Fundacao para a Ciencia e Tecnologia (FCT, Lisbon, Portugal)
- FEDER (European Union) [IF/00092/2014/CP1255/CT0004]
- Fundacao Manuel Antonio da Mota (FMAM, Porto, Portugal)
- Fundação para a Ciência e a Tecnologia [PD/BD/135458/2017] Funding Source: FCT
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Cationic antimicrobial peptides (CAMPs) can be considered as new potential therapeutic agents for Tuberculosis treatment with a specific amino acid sequence. New studies can be developed in the future to improve the pharmacological properties of CAMPs and also understand possible resistance mechanisms. This review discusses the principal properties of natural and/or synthetic CAMPs, and how these new peptides have a significant specificity for Mycobacterium tuberculosis. Also, we propose some alternative strategies to enhance the therapeutic activity of these CAMPs that include co-administration with nanoparticles and/or classic drugs.
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