Journal
CURRENT ORGANIC CHEMISTRY
Volume 23, Issue 5, Pages 530-615Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1385272823666190401141844
Keywords
Arbuzov reaction; bioactive compounds; bisphosphonates; bisphosphonic acids; bisphosphonate complexes; cycloaddition reactions; diazobisphosphonates; enzyme inhibitors; insertion reactions; medicinal chemistry; modified polyphosphates; Michaelis-Becker reaction; multicomponent reactions; phosphate mimics; phosphonates; phosphonate carbanions; phosphonic acid group; pyrophosphate analogues; synthetic methods; trisphosphonates; Michael addition; phosphonylating reactions
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Funding
- National Academy of Science of Ukraine [04-03-18]
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Functionalized gem-bisphosphonic acid derivatives being pyrophosphate isosteres are of great synthetic and biological interest since they are currently the most important class of drugs developed for the treatment of diseases associated with the disorder of calcium metabolism, including osteoporosis, Paget's disease, and hypercalcemia. In this article, we will try to give an in-depth overview of the methods for obtaining alpha-heteroatom-substituted methylenebisphosphonates and acquaint the reader with the synthetic strategies that are used to develop biologically important compounds of this type.
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