Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 58, Issue -, Pages 259-268Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2019.05.022
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Funding
- Lundbeck Foundation
- National Institute of Health [R01NS047723, R01GM098672, P01GM111126, S10OD020054, S10OD021741]
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Advances in electron microscopes, detectors and data processing algorithms have greatly facilitated the structural determination of many challenging integral membrane proteins that have been evasive to crystallization. These breakthroughs facilitate the application and development of various membrane protein solubilization approaches for structural studies, including reconstitution into lipid nanoparticles. In this review, we discuss various approaches for preparing transmembrane proteins for structural determination with single-particle electron cryo microscopy (cryoEM).
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