Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 56, Issue -, Pages 194-198Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2019.03.001
Keywords
-
Categories
Funding
- N.I.H. [RO1 NS078164]
- N.I.H. (Conte Center)
- US National Institutes of Health BRAINS Award [MH107800]
- NYSCF Robertson Stem Cell Investigator Award
- Chan Zuckerberg Initiative Ben Barres Investigator Award
- Stanford Bio-X
- Stanford University
- Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard
Ask authors/readers for more resources
The development and wiring of the central nervous system is a remarkable biological process that starts with the generation of and interaction between a large diversity of cell types. Our understanding of the developmental logic that drives cellular diversification in the mammalian brain comes, to a large extent, from studies in rodents. However, identifying the unique cellular processes underlying primate corticogenesis has been slow, due to the challenges associated with directly observing and manipulating brain tissue from these species. Recent technological advances in two areas hold promise to accelerate discovery of the mechanisms that govern human brain development, evolution, and pathophysiology of disease. Molecular profiling of large numbers of single cells can now capture cell identity and cell states within a complex tissue. Furthermore, modeling aspects of human organogenesis in vitro, even for tissues as complex as the brain, has been advanced by the use of three-dimensional organoid systems. Here, we describe how these approaches have been applied to date and how they promise to uncover the principles of cell diversification in the developing human brain.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available