Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 58, Issue -, Pages 1-7Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2018.11.004
Keywords
-
Categories
Funding
- DFG: Deutsche Forschungsgemeinschaft [KE 660 14-1, KE 660 16-1, SFB860, SFB1190]
Ask authors/readers for more resources
The molecular mechanisms of nuclear transport have been described in great detail and we are beginning to understand the structures of transport complexes and even of subcomplexes of the nuclear pore at an atomic or near-atomic resolution. The complexity of the clients that use the transport machinery, by contrast, is less well understood, although some transport receptors are reported to have hundreds of different cargoes and others only a few. Here, we review the recent attempts to define the cargo spectrum of individual nuclear transport receptors using bioinformatic, biochemical and cell biological approaches and compare the results obtained by these complementary methods. Remarkably, a large fraction of the soluble proteome can be subject to nucleocytoplasmic transport.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available