Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 58, Issue -, Pages 76-84Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2019.02.006
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Funding
- NIH [GM105847, CA193419, K99GM123195]
- [DK107980]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [K99GM123195, R01GM105847] Funding Source: NIH RePORTER
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The cell nucleus encloses, organizes, and protects the genome. Chromatin maintains nuclear mechanical stability and shape in coordination with lamins and the cytoskeleton. Abnormal nuclear shape is a diagnostic marker for human diseases, and it can cause nuclear dysfunction. Chromatin mechanics underlies this link, as alterations to chromatin and its physical properties can disrupt or rescue nuclear shape. The cell can regulate nuclear shape through mechanotransduction pathways that sense and respond to extracellular cues, thus modulating chromatin compaction and rigidity. These findings reveal how chromatin's physical properties can regulate cellular function and drive abnormal nuclear morphology and dysfunction in disease.
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