Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 57, Issue -, Pages 127-136Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2019.03.010
Keywords
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Funding
- Water Research Foundation [4721]
- Cystic Fibrosis Foundation [LIPUMA15G0]
- National Science Foundation Graduate Research Fellowship [DGE 1256260]
- NWRI-BioLargo Fellowship for Water Science Research
- Alfred P. Sloan Foundation Microbiology of the Built Environment fellowship [G-2014-13739, G-2016-7250]
- University of Michigan Dow Sustainability postdoctoral fellowship
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Nontuberculous mycobacteria (NTM) pulmonary infections are a growing concern worldwide, with a disproportionate incidence in persons with pre-existing health conditions. NTM have frequently been found in municipally-treated drinking water and building plumbing, leading to the hypothesis that an important source of NTM exposure is drinking water. The identification and quantification of NTM in environmental samples are complicated by genetic variability among NTM species, making it challenging to determine if clinically relevant NTM are present. Additionally, their unique cellular features and lifestyles make NTM and their nucleic acids difficult to recover. This review highlights a recent work focused on quantification and characterization of NTM and on understanding the influence of source water, treatment plants, distribution systems, and building plumbing on the abundance of NTM in drinking water.
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